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Prescribing information describes gastrointestinal adverse reactions as common, particularly during dose escalation, and clinicians typically individualize titration based on tolerability and patient history

While reduced appetite is the mechanism driving weight loss, extreme caloric restriction creates problems that extend beyond just feeling tired

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This means knowing the biological and psychological history of the subject, identifying relational and biological crisis factors, and building personalized treatments targeting those factors with the tools of medicine and psychology, which are not reducible to the combination of drugs and psychotherapy

Dehydration is a particular concern in older adults